diff --git a/meson.build b/meson.build
index bc0c8c5d..1dbc15fc 100644
--- a/meson.build
+++ b/meson.build
@@ -15,13 +15,15 @@ pkgconfig = import('pkgconfig')
 i18n = import('i18n')
 
 libsysprof_api_version = 4
+libsysprof_ui_api_version = 5
+
 version_split = meson.project_version().split('.')
 datadir = get_option('datadir')
 datadir_for_pc_file = join_paths('${prefix}', datadir)
 podir = join_paths(meson.current_source_dir(), 'po')
 
-glib_req_version = '>= 2.67.4'
-gtk_req_version = '>= 3.22'
+glib_req_version = '>= 2.68.0'
+gtk_req_version = '>= 4.4'
 polkit_req_version = '>= 0.105'
 
 cc = meson.get_compiler('c')
diff --git a/src/libsysprof-ui/meson.build b/src/libsysprof-ui/meson.build
index 92ad1122..2ad83acc 100644
--- a/src/libsysprof-ui/meson.build
+++ b/src/libsysprof-ui/meson.build
@@ -88,7 +88,7 @@ libsysprof_ui_resources = gnome.compile_resources(
 # Subset of dependencies used in generating the pkg-config file
 libsysprof_ui_pkg_deps = [
   dependency('gio-2.0', version: glib_req_version),
-  dependency('gtk+-3.0', version: gtk_req_version),
+  dependency('gtk4', version: gtk_req_version),
 ]
 
 libsysprof_ui_deps = libsysprof_ui_pkg_deps + [
@@ -100,7 +100,7 @@ libsysprof_ui_deps = libsysprof_ui_pkg_deps + [
 libsysprof_ui_pkg_deps += libsysprof
 
 libsysprof_ui = shared_library(
-  'sysprof-ui-@0@'.format(libsysprof_api_version),
+  'sysprof-ui-@0@'.format(libsysprof_ui_api_version),
   libsysprof_ui_public_sources + libsysprof_ui_private_sources + libsysprof_ui_resources,
 
            dependencies: libsysprof_ui_deps + [librax_dep],
@@ -121,7 +121,7 @@ pkgconfig.generate(
       subdirs: [ sysprof_header_subdir ],
   description: 'The UI library for GTK applications embedding sysprof',
   install_dir: join_paths(get_option('libdir'), 'pkgconfig'),
-     requires: [ 'gio-2.0', 'gtk+-3.0' ],
+     requires: [ 'gio-2.0', 'gtk4' ],
      libraries_private: libsysprof_ui_pkg_deps,
      variables: [
        'datadir=' + datadir_for_pc_file,
diff --git a/src/tests/meson.build b/src/tests/meson.build
index f7703eec..d1593cba 100644
--- a/src/tests/meson.build
+++ b/src/tests/meson.build
@@ -122,7 +122,7 @@ if get_option('enable_gtk')
   test_ui_deps = [
     libsysprof_dep,
     libsysprof_ui_dep,
-    dependency('gtk+-3.0', version: gtk_req_version),
+    dependency('gtk4', version: gtk_req_version),
     dependency('pangoft2', required: false),
   ]